Serum Levels of Macrophage Inflammatory Protein -1α (MIPs-1 α) as a Potential Biomarker in Periodontal Disease with post-radiation Head and Neck Cancer Patients

Awad, Sameer A.; Al-Kubaisi, Ahmed A.; Mukhlif, Mahmood Y; Fezea, Alaa Ahmed; Aldelaimi, Ekram R.; Mssdf, Abdulrahman Khalid

doi:10.24271/psr.2025.526990.2164

Serum Levels of Macrophage Inflammatory Protein -1α (MIPs-1 α) as a Potential Biomarker in Periodontal Disease with post-radiation Head and Neck Cancer Patients

Document Type : Original Article

Authors

Sameer A. Awad ¹

Ahmed A. Al-Kubaisi ²

Mahmood Y Mukhlif ³

Alaa Ahmed Fezea

Ekram R. Aldelaimi

Abdulrahman Khalid Mssdf

¹ Department of Clinical and Laboratory Science, College of Pharmacy, University of Anbar, Ramadi 31001, Iraq.

² Department of Medical Laboratories Techniques, College of Health and Medical Technology, University of Al Maarif, Ramadi 31001, Iraq.

³ Department of Antimicrobial Resistance, Al-Anbar Health Directorate, Ministry of Health, Ramadi 31001, Iraq.

10.24271/psr.2025.526990.2164

Abstract

Proinflammatory chemokines positivity is exhibited by Macrophage Inflammatory Protein -1α (MIP-1α) in the presence of inflammation and chronic infections. The present research included 150 individuals, including n=50 for patients who were affected by head and neck cancer, and who had radiation more than six months ago, n=50 patients with chronic periodontitis (CP), and n=50 controls. Clinical periodontal parameters were documented to record periodontal scores. An enzyme-linked immunosorbent test (ELISA) was developed to quantify blood MIPs-1α concentrations. Individuals diagnosed with chronic periodontitis following radiotherapy for head and neck cancer. They had a markedly elevated concentration of MIP-1α (102.65 pg/ml) compared to those with chronic periodontitis and the control group (63.25 and 46.09, respectively). The correlation between serum MIP-1α levels and clinical periodontal markers in chronic periodontal disease was found to be significantly positive. This case-control study suggests that elevated blood MIP-1α levels in head and neck cancers (HNCs) after radiotherapy may serve as indicators of periodontal tissue degradation.

Keywords

Head and neck cancer

Chronic periodontitis

MIP-1α

Radiotherapy