Document Type : Original Article


1 pharmaceutical chemistry, College of Medical and Applied Sciences, Charmo University

2 Department of chemistry, college of science, University of Garmian, Kalar, Kurdistan region, Iraq

3 Applied Chem., College of Medical and Applied Sciences, Charmo University



Sperm motility is necessary for regular fertilization because spermatozoa must travel far in the female genitaltract to defuse and fertilize the oocyte. Low sperm motility, also known as as thenozoospermia (AZ), is a prevalent cause of infertility in men. AZ is defined as a low percentage of forwarding (progressive motility), fewer than 30%, or a lack of sperm motility in examined total ejaculation. Reduced sperm motility may result from an unhealthy lifestyle, obesity, environmental pollution, oxidative stress, smoking, alcohol intake, or may be idiopathic. Oxidative may damage different sperm components like DNA, proteins, or lipids.This study aims to determine a possible relationship between semen antioxidants, lipid peroxidation, and sperm motility parameters in asthenozoospermic men.Twenty-three healthy fertile males and 57 AZ infertile men were included in this study. Samples were obtained after 3-4 days of abstinence from sexual intercourse. Exclusion criteria included medication use, smoking, drinking alcohol, chronic illness(such as diabetes mellitus, hypertension, etc.), varicocele and high viscid samples.
The results revealed a remarkable decrease in superoxide dismutase activity and a high increase in semen plasma malondialdehyde in the asthenozoospermic group. The decrease in SOD activity leads to an increase in superoxide anionlevel (O2•‾), which induces lipid peroxidation in the spermatozoa membrane.Lipid peroxidation frequently affects spermatozoa motility by affecting sperm membrane and fluidity and followed by mitochondrial defect and a concomitant decrease in energy generation.


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